Diagnosis Technology

Diagnosis of Alzheimer Disease

Alzheimer disease is currently the most common dementia in our society. Its clinical manifestations were described in early twentieth century by Emil Kraepelin, and description of lesions in the central nervous system were described by Alois Alzheimer.

Alzheimer disease is featured by recent memory impairment (initially mere details of daily life), disorientation, inability to recognize familiar people, decreased intellectual performance and language issues that lead to the loss of language ability. Motor skills are also impaired, including eye movement.

The diagnosis of dementia is made through a number of criteria and procedures defined by experts. Until now, there is no evidence of a definitive diagnosis technique, and certainty can only be achieved late, by means of pathologic studies in the autopsy. However, growing evidence supports surrogate techniques of diagnosis, such as neuropsychological tests, cephaloraquid liquid biomarkers or nuclear imaging techniques. Eye movement analysis combined with other clinical data could improve the reliability of the diagnosis process.

CuratorIrene Pulido, MD, PhD
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